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The pharmacologic synergy between tirzepatide and metformin stems from their distinct yet complementary mechanisms of action targeting different aspects of glucose homeostasis
Adding once-daily lixisenatide for type 2 diabetes inadequately controlled by established basal insulin: a 24-week, randomized, placebo-controlled comparison (GetGoal-L)
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Controlling glucose levels: In the pancreas, the proglucagon can convert into glucagon, which in turn signals the liver to release glucose
Biochemical analysis further revealed that semaglutide significantly lowered AST, TG, and TC, although with a slight increase in serum ALT levels (Fig.5-E, F, G, H)
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